PlanYourVitamins.com

When to take
Nettle Root

The common nettle, once dried and processed, is a herb with a long traditional history, and the modern research around it has looked at joint health, blood pressure and prostate health.

What is nettle root good for?

Short answer: Nettle root is studied for prostate health and inflammation.
Nettle root supplements are extracted from the roots of the Urtica dioica plant, also known as stinging nettle, or simply common nettle, a perennial flowering plant that is native to Europe and parts of Asia, although it can now be found across the globe.

History and characteristics

The name Urtica dioica is derived from the Latin word "uro", which means "to burn", as anyone who has had the misfortune of brushing their leg against nettles while on a summer walk will happily agree.

This is because the plant is bristling with hundreds of trichomes, hollow stinging hairs on its leaves and stems which, for all intents and purposes, act precisely like hypodermic needles, injecting histamine and other mildly irritating chemicals that produce the characteristic burning sensation.

The stinging mechanism of the nettle is achieved by hundreds of tiny bristling needles that inject histamine and other irritants upon contact.
The stinging mechanism of the nettle is achieved by hundreds of tiny bristling needles that inject histamine and other irritants upon contact.


However, once the plant has been dried or cooked, the stinging aspect of the nettle is mostly neutralized and it can be safely consumed. Several parts of the nettle plant have been a staple in medicine for thousands of years, dating back as far as the ancient Egyptians, who would use nettle for complaints such as arthritis, and perhaps blood pressure too.

Nettle root for inflammation and arthritis

These properties also appear in modern research, where several compounds found within nettle are studied in relation to inflammation.

For example, multiple in vitro and animal studies have looked at nettle extract supplementation and the levels of several inflammatory markers. Furthermore, modern human studies have looked at nettle products applied topically and at symptoms associated with arthritis.

Similar results have been reported when nettle extract was taken orally as a supplement, with less pain associated with arthritis, and participants in that study reported lower use of standard painkillers.

Nettle root for prostate health

Benign prostatic hyperplasia, also known as enlarged prostate or simply BPH, is a debilitating condition that can affect up to 50% of men over the age of 50.

There is a growing body of research into nettle extract supplementation and BPH, and the way it relates to the conversion of testosterone into dihydrotestosterone, a process which is thought to contribute to the development of BPH.

Nettle root for blood pressure, blood sugar and cardiovascular health

Several animal and in vitro studies have looked at nettle extract supplementation and high blood pressure, and it appears to achieve this through a number of mechanisms.

On one hand, it is thought to sit with nitric oxide production, a chemical the research associates with blood vessels, blood flow and the pressure exerted on artery walls. On the other hand, some of the compounds found within nettle function as calcium blockers, meaning that they relax muscles and reduce the force exerted by the heart during contractions.

Additionally, multiple studies have looked at nettle supplementation and lower blood sugar levels, and it is thought that this is due to the way in which some of nettle's compounds replicate the function of insulin.

One particular study that involved 46 people taking 500mg of nettle extract three times daily reported lower blood sugar levels over the course of three months, compared to the group that took a placebo.

When should I take nettle root?

Short answer: Nettle root supplements are best taken with any meal.

There does not currently appear to be a clear consensus on whether nettle root should be taken in the morning or at night, however most manufacturers recommend taking it with a meal.

What else pairs well with nettle root?

Short answer: While not found to provide additional benefits when taken at the exact same time, research has shown that nettle root pairs well with pygeum and saw palmetto extract.

Also taken with saw palmetto extract, for prostate health

Both nettle root and saw palmetto extract are studied in benign prostatic hyperplasia, or BPH, which involves the prostate becoming enlarged to the point where urination is made quite difficult.

There is research that looks at the benefits of taking both nettle root and saw palmetto extract together, compared with the supplements taken individually.

Also taken with pygeum, for prostate health and BPH

Taken together, nettle root and pygeum also cover prostate health, inflammation and BPH, so the two are usually kept side by side.

What are natural sources of nettle root?

Stinging nettle is a perennial plant of hedgerows and disturbed ground across Europe, Asia and North America. The leaves are a familiar spring vegetable, blanched into soup, folded into dumplings or dried for tea, and cooking or drying takes the sting out entirely. The root is woody and bitter, taken as a decoction or tincture, and a strong cup brewed from dried root gives a modest, variable dose beside the measured extract in a capsule.

Who should avoid taking nettle root?

Short answer: Avoid taking nettle root supplements if you have low blood pressure or kidney problems.

Before taking nettle root supplements, check with your trusted healthcare professional if any of the following apply to you:

  • Low blood pressure
  • Kidney problems

Kidney problems and low blood pressure

A diagnosed kidney condition, or blood pressure readings that are already low, are the situations where the extract can unnecessarily cause additional problems.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional if you are suffering from any health conditions.

Possible side effects of nettle root

Short answer: Side effects of nettle root supplements can include sweating, gastrointestinal upset and diuresis.

Possible side effects from taking nettle root supplements may include (but are not limited to) the following:

  • Sweating
  • Gastrointestinal upset
  • Diuresis

If you are experiencing negative side effects from taking nettle root supplements, stop taking them immediately and reach out to your trusted healthcare professional.

Drug interactions with nettle root

Short answer: Nettle root supplements can interact with blood thinners, benzodiazepines & sedatives, blood pressure medicines, diabetes medicines and lithium.

The medicines listed below are the ones most often named in interaction reports for nettle root, but it is by no means a comprehensive list:

  • Blood thinners
  • Benzodiazepines & sedatives
  • Blood pressure medicines
  • Diabetes medicines
  • Lithium

If you are taking any prescription drugs or medication, check with your trusted healthcare professional before taking nettle root supplements.

Can I take nettle root while pregnant or breastfeeding?

Short answer: Nettle root supplements should be avoided during pregnancy and breastfeeding.

The root has a mild diuretic effect, and no human pregnancy trials exist, so it is advisable to not take it during pregnancy until further research appears.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional while pregnant or breastfeeding, or while attempting to conceive.

Where should I store nettle root?

Short answer: You can store nettle root supplements in the cupboard.

For optimal shelf life, it is recommended to keep nettle root supplements stored in the cupboard. Always make sure the bottle or container is tightly closed, and kept away from sources of light, heat and humidity.

Nettle root data sources & further reading

  1. 1.
  2. 2.
  3. 3.
  4. 4.
  5. 5.
  6. 6.
  7. 7.
  8. 8.
  9. 9.
  10. 10.

Last updated October 29th, 2026

Remember

A balanced diet and a healthy lifestyle always come first, and supplements are meant to be just that: supplementary. While every effort has been made to ensure that the data on this page is accurate, said accuracy can never be guaranteed. The information provided is not medical advice, it is not intended to cover all possible interactions or adverse effects, and neither is it a substitute for the expertise of professional healthcare practitioners. You are always encouraged to do your own research, and to consult with your trusted doctor or pharmacist before taking any supplements.

Read our FAQ »

We use cookies to save your site preferences and manage site traffic.

More info