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Collagen

Collagen forms the structural framework for bones, muscles, skin, tendons, ligaments, organ membranes, and many other connective tissues.

What is collagen good for?

Short answer: Collagen is studied for joint health, skin health, bone health, hair health and nail health.
Did you know that collagen is the most abundant protein in your body? It forms roughly 30% of your body's total protein content, as it is the primary building block of your bones, muscles, joints, tendons and skin, along with a variety of other connective tissues and organ membranes.

Your body is able to produce its own collagen, ensuring all of these different tissues remain healthy and functional, but as you get older, two things start to happen: your body starts to produce less collagen, and the collagen that you do have begins to deteriorate. This can result in a number of debilitating diseases and conditions that become increasingly common the older you get.

Collagen supplementation is the subject of a great deal of research into exactly those changes.

Collagen is the most abundant protein in the human body, and forms the structural framework for our skin, bones, muscles, tendons, ligaments, connective tissues and organ membranes.
Collagen is the most abundant protein in the human body, and forms the structural framework for our skin, bones, muscles, tendons, ligaments, connective tissues and organ membranes.


For skin health

For example, one of collagen's most popular applications is in the area of skin health, and several studies have reported that collagen supplements reduce wrinkles and increase skin hydration and skin elasticity.

A review of 26 studies found that women who took between 1g and 12g of collagen daily for several months observed changes in skin elasticity and skin hydration.

Role in bone and joint health

It is easy enough to assume that bones are composed mostly from calcium, and this is how I thought until very recently, but bones are actually mostly made from collagen.

Osteoporosis, which is a reduction in bone density associated with older age, is a direct result of the aforementioned reduction in your body's ability to produce collagen, and the deterioration of existing collagen.

Similarly, osteoarthritis is a deterioration of the collagen in your joints. Several studies have reported less joint pain with collagen supplementation in people with osteoarthritis.

Role in cardiovascular health

Collagen even forms part of your veins and arteries. In fact, with insufficient collagen, your arteries become less flexible and lose elasticity, which can lead to atherosclerosis, which is essentially a narrowing of the arteries, and one of the leading causes globally of heart attacks and strokes.

One study involving 30 healthy adults who took 16g of collagen daily for a duration of six months found changes in overall artery flexibility and elasticity. Very interesting!

When should I take collagen?

Short answer: Collagen supplements are best taken in the evening or at bedtime.

Collagen peptides are best absorbed with a glass of water or coffee, although they can be taken with food too. There is no strict rule about taking it on an empty stomach, so you can mix it in with smoothies if that suits your routine better.

One small trial did give 15 g of collagen peptides in water about an hour before bed, without food, in athletic men with sleep complaints, and saw fewer night-time awakenings, which is why a bedtime scoop is a reasonable experiment if improved sleep is the main reason why you are trying it. Personally I have found that taking it immediately before bed made me feel discomfort, so taking it perhaps one our before bed is ideal.

The glycine in collagen is involved in pathways that include serotonin and melatonin, which is the biochemical reason for its sleep benefits, but if a large evening dose sits uncomfortably, start with a smaller dose, or simply move it to be taken with a meal instead.

What does collagen combine well with?

Short answer: Collagen is best taken in the same sitting as citrus fruits.

Citrus fruit is a great partner for collagen, because the vitamin C in the fruit is needed for the enzymes that cross-link collagen, so a collagen serving with a glass of orange juice or a handful of berries gives your body the vitamin C cofactor that its work depends on.

What else pairs well with collagen?

Short answer: While not found to provide additional benefits when taken at the exact same time, research has shown that collagen pairs well with eggshell membrane, gotu kola, hyaluronic acid, l-glutamine, silica and vitamin C.

Also taken with vitamin C, for collagen synthesis

Vitamin C is known to promote collagen synthesis, as it is a key ingredient during the production of two specific molecules that are essential for collagen production. Several studies in people with bone fractures reported faster healing and scar tissue formation with vitamin C supplementation than in the control groups.

Also taken with glutamine, for collagen synthesis

Another study found that taking glutamine can also help stimulate collagen synthesis too, so the two are often taken alongside collagen, especially during recovery from a bone fracture.

Also taken with eggshell membrane, for joint health and inflammation

The case for taking eggshell membrane with collagen rests on joint health, skin health and inflammation, which the pair covers.

Also taken with hyaluronic acid, for joint health and skin health

Hyaluronic acid is often kept alongside collagen because they both contribute towards joint health.

Also taken with gotu kola, for skin health and brain health

Collagen and gotu kola can share a sitting because between them they cover joint health, skin health and brain health.

Also taken with silica, for skin, hair and nails

Silica plays a role in the collagen and keratin structures in your skin, hair and nails.

What are natural sources of collagen?

Short answer: Natural sources of collagen include bone broth, chicken, oily fish and eggs.

If you are interested in obtaining your daily collagen through your diet, you can often find it in:

Who should avoid taking collagen?

Short answer: Avoid taking collagen supplements if you have fish allergy or bovine allergy.

Before taking collagen supplements, check with your trusted healthcare professional if any of the following apply to you:

  • Fish allergy
  • Bovine allergy

Fish or bovine allergy

Collagen capsules come from two sources, fish skin and scales for the marine products and cattle hide for the bovine ones, so a known allergy to either protein is the reason to pick one type over the other.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional if you are suffering from any health conditions.

Possible side effects of collagen

Short answer: Side effects of collagen supplements can include fullness and allergic reaction (rare).

Possible side effects from taking collagen supplements may include (but are not limited to) the following:

  • Fullness
  • Allergic reaction (rare)

Most people notice little from a collagen powder beyond fullness when a scoop is taken on an empty stomach, and a larger serving is the usual reason it sits heavily.

An allergic reaction is rare, and it shows up as hives, itching, swelling of the lips or a wheeze, most often in someone who already reacts to fish or to beef, which is why the first scoop is easiest to judge at home.

If you are experiencing negative side effects from taking collagen supplements, stop taking them immediately and reach out to your trusted healthcare professional.

Can I take collagen while pregnant or breastfeeding?

Short answer: Collagen supplements are safe to take during pregnancy and breastfeeding.

Collagen is a protein, and the food version is ordinary during pregnancy: broth, meat, fish and eggs all supply the amino acids it's made from. Collagen peptides sold as a powder have little pregnancy data, and they aren't a complete protein, so they don't replace the protein foods you need. The vitamin C that helps your body cross-link collagen is the part with a real requirement.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional while pregnant or breastfeeding, or while attempting to conceive.

Where should I store collagen?

Short answer: You can store collagen supplements in the cupboard.

For optimal shelf life, it is recommended to keep collagen supplements stored in the cupboard. Always make sure the bottle or container is tightly closed, and kept away from sources of light, heat and humidity.

Collagen data sources & further reading

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    Dietary Supplement Fact Sheets

    NIH Office of Dietary SupplementsGovernment guidance

    https://ods.od.nih.gov/factsheets/list-all/Visit https://ods.od.nih.gov/factsheets/list-all/

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Last updated October 29th, 2026

Remember

A balanced diet and a healthy lifestyle always come first, and supplements are meant to be just that: supplementary. While every effort has been made to ensure that the data on this page is accurate, said accuracy can never be guaranteed. The information provided is not medical advice, it is not intended to cover all possible interactions or adverse effects, and neither is it a substitute for the expertise of professional healthcare practitioners. You are always encouraged to do your own research, and to consult with your trusted doctor or pharmacist before taking any supplements.

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