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When to take
L-Tyrosine

L-tyrosine is involved in the formation of many important proteins, enzymes and hormones, including dopamine, adrenaline and melanin.

What is l-tyrosine good for?

Short answer: L-tyrosine is studied for stress, thyroid function and mental health.
L-tyrosine is an important amino acid that is found in foods that are habitually high in protein, such as fish, meat, and in particular cheese, which is where it was first discovered, and where it gets its name from. "Tyrós" in fact means "cheese" in Greek.

However, the fact that "tyrosine" also plays an important role in the "thyroid" gland is actually a coincidence, as the modern name for the thyroid gland dates back to the 1600s, when British anatomist Thomas Wharton named the gland after the Ancient Greek word "thyreoidea", which means "shield-like".

The name for tyrosine is derived from the Greek word for cheese, where it was first discovered.
The name for tyrosine is derived from the Greek word for cheese, where it was first discovered.


L-tyrosine's role in hormone production

L-tyrosine is used by the body in the formation of proteins, and also assists in the production of enzymes, as well as several important hormones. For example, dopamine, adrenaline and melanin are all produced with the assistance of L-tyrosine, as is thyroxine, the primary form of thyroid hormone.

That said, while L-tyrosine forms an integral part of thyroid hormone production, supplementation should be done with caution, as too much L-tyrosine could interfere with the thyroid's natural function.

L-tyrosine's role in nerve health

L-tyrosine is also conducive to healthy nerve signal communication and neurotransmitter function, and is also known to help reverse reductions in cognitive ability that are associated with neurological stress.

When should I take l-tyrosine?

Short answer: L-tyrosine supplements are best taken shortly before a meal, early in the day, or pre-workout.

L-tyrosine is best taken approximately 30 minutes before a meal in order to maximize absorption. If you are taking L-tyrosine for physical performance, it is considered optimal to take it between 30 and 60 minutes before exercise. Also, when taken late in the day, it has the potential to keep you awake, so the morning or early afternoon is the ideal time to take it.

What does l-tyrosine combine well with?

Short answer: L-Tyrosine is best taken in the same sitting as l-theanine and caffeine.

L-tyrosine with L-theanine and caffeine

Another study found that by combining L-tyrosine with low-dose caffeine and l-theanine, there was a change in the movement accuracy of athletes while undergoing exhaustive exercise.

What else pairs well with l-tyrosine?

Short answer: While not found to provide additional benefits when taken at the exact same time, research has shown that l-tyrosine pairs well with copper, vitamin B6 and vitamin B9.

Also taken with copper, vitamin B6 & vitamin B9

Studies have shown that by combining L-tyrosine with copper and vitamins B6 and folic acid (vitamin B9), it is possible to enhance L-tyrosine's production of hormones. For example, vitamin B6 appears to help L-tyrosine during the production of the hormone dopamine.

What should I avoid taking l-tyrosine with?

Short answer: Avoid taking l-tyrosine supplements at the same time as l-phenylalanine.

Avoid taking l-tyrosine at the same time as l-phenylalanine

L-phenylalanine is one enzymatic step before l-tyrosine, and the two share the same large neutral amino acid transporter in the gut. A capsule of each in one sitting crowds that single route and makes them compete for absorption, so putting a few hours between them is the ideal arrangement.

What are natural sources of l-tyrosine?

Short answer: Natural sources of l-tyrosine include beef, pork, salmon, turkey, eggs, milk, cheese, yogurt and legumes & beans.

If you are interested in obtaining your daily l-tyrosine through your diet, you can often find it in:

Who should avoid taking l-tyrosine?

Short answer: Avoid taking l-tyrosine supplements if you have thyroid conditions or melanoma history.

Before taking l-tyrosine supplements, check with your trusted healthcare professional if any of the following apply to you:

  • Thyroid conditions
  • Melanoma history

Hyperthyroidism or Graves disease

Given L-tyrosine's capacity to increase levels of the thyroid hormone thryoxine, it is advisable that people suffering from conditions such as hyperthyroidism or Graves disease should avoid taking supplements containing tyrosine altogether.

Melanoma history

Tyrosine is one of the raw materials the body uses to make melanin, the pigment in skin, hair and eyes, and that link is where the melanoma note on this page comes from. There is no definitive or conclusive research on l-tyrosine's effects on melanoma yet, but if you have a history of melanoma you should discuss this with your doctor before starting l-tyrosine supplements.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional if you are suffering from any health conditions.

Possible side effects of l-tyrosine

Short answer: Side effects of l-tyrosine supplements can include heartburn and headache.

Possible side effects from taking l-tyrosine supplements may include (but are not limited to) the following:

  • Heartburn
  • Headache

If you are experiencing negative side effects from taking l-tyrosine supplements, stop taking them immediately and reach out to your trusted healthcare professional.

Drug interactions with l-tyrosine

Short answer: L-tyrosine supplements can interact with antidepressants, levodopa and levothyroxine.

The medicines listed below are the ones most often named in interaction reports for l-tyrosine, but it is by no means a comprehensive list:

  • Antidepressants
  • Levodopa
  • Levothyroxine

If you are taking any prescription drugs or medication, check with your trusted healthcare professional before taking l-tyrosine supplements.

Can I take l-tyrosine while pregnant or breastfeeding?

Short answer: L-tyrosine supplements do not have sufficient safety data during pregnancy and breastfeeding.

No human trials have looked at a high-dose capsule during pregnancy. It's mildly activating, and a supplement taken for focus isn't a nutrient your baby is short of, so the best advice is to avoid it until more research surfaces.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional while pregnant or breastfeeding, or while attempting to conceive.

Where should I store l-tyrosine?

Short answer: You can store l-tyrosine supplements in the cupboard.

For optimal shelf life, it is recommended to keep l-tyrosine supplements stored in the cupboard. Always make sure the bottle or container is tightly closed, and kept away from sources of light, heat and humidity.

One more thing regarding l-tyrosine

N-Acetyl-L-tyrosine (NALT)

Some nootropic and pre-workout blends use N-Acetyl-L-tyrosine (NALT) instead of free-form L-tyrosine. It dissolves more easily in water, but for ordinary oral capsules the evidence still sits mainly with L-tyrosine itself, so if the bottle simply says L-tyrosine you are on the more common product.

L-tyrosine data sources & further reading

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    Metabolite: MedlinePlus Medical Encyclopedia

    MedlinePlus, U.S. National Library of MedicineGovernment guidance

    https://medlineplus.gov/ency/article/002258.htmVisit https://medlineplus.gov/ency/article/002258.htm

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Last updated October 31st, 2026

Remember

A balanced diet and a healthy lifestyle always come first, and supplements are meant to be just that: supplementary. While every effort has been made to ensure that the data on this page is accurate, said accuracy can never be guaranteed. The information provided is not medical advice, it is not intended to cover all possible interactions or adverse effects, and neither is it a substitute for the expertise of professional healthcare practitioners. You are always encouraged to do your own research, and to consult with your trusted doctor or pharmacist before taking any supplements.

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