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Garlic Extract

Garlic extract has a strong antioxidant profile, and the research around it has looked at heart health, the immune system and bone health.

What is garlic extract good for?

Short answer: Garlic extract is studied for heart health, cholesterol levels and circulation.
Garlic is a flowering plant in the onion family that is grown in many parts of the world, and its distinct bulb is an extremely popular ingredient in most, if not all cuisines around the world, thanks to its distinct aroma and powerful taste, although I'm sure you probably already knew that!

In addition to its culinary importance, garlic has also been used for millennia for medicinal purposes, with documented usage dating back to ancient Egyptians, Greeks, Romans and Chinese, to name but a few. In more recent times, garlic extract aims to provide these compounds in a refined, concentrated form.

Nutritional value of garlic

Garlic also carries trace minerals such as selenium and manganese, as well as vitamin C and vitamin B6, although much of its activity comes from compounds that only form when fresh garlic cloves are crushed or chopped, namely a compound called allicin.

However, allicin is unstable, in the sense that it is only available for a brief period after formation, so it is important to consume fresh garlic shortly after preparation in order to take advantage of the allicin compounds that it so kindly provides.

Allicin, the principle compound found in garlic, is only available for a short period after the garlic has been chopped or crushed.
Allicin, the principle compound found in garlic, is only available for a short period after the garlic has been chopped or crushed.


Effects on the immune system

Research shows that many of garlic's compounds have antioxidant and antiviral properties, and they are studied for the immune system, including their effect on how viruses enter cells, and on how they replicate within cells they may have already entered.

A study performed in 2016 looked at aged garlic extract taken for the duration of the flu season, measuring symptom severity and recovery, and the reported figures were kinder to the garlic group.

These same compounds are also studied in cancer research, including their effect on how a cancerous cell duplicates, and on cancer cell death, a process known as apoptosis.

Effects on the cardiovascular health

Garlic is also studied for cholesterol levels, in particular its effect on LDL, which we understand to be the bad form of cholesterol. Several studies have reported lower LDL cholesterol from incorporating garlic into the diet, or from taking garlic extract supplementation for several months.

They also found it to be of particular interest in people that already have high cholesterol levels.

Garlic is also known for its blood-thinning effect and is studied for blood pressure, including in people that have high blood pressure. Research has also looked at garlic supplements and its effect at reducing cardiovascular events.

Bone health

All of these factors combine to make garlic a familiar part of cardiovascular research, and garlic also has other, lesser known areas of interest. For example, did you know that garlic is also studied for bone health? I only found this out very recently.

Studies have looked at garlic supplementation and calcium absorption, as well as oxidative stress on bone structure, and it is also studied in bone conditions such as osteoporosis.

So there you have it. Add extra garlic to your meal tonight!

Aged Garlic Extract (AGE)

In addition to garlic extract, you have no doubt also heard of "Aged Garlic Extract", also known as AGE. This is a proprietary form of garlic extract produced under the Kyolic brand by the company Wakunaga, made by aging the garlic through a special procedure that can last up to 20 months.

Several key properties of the garlic are modifed when undergoing the aging process, perhaps most the most important being the stabilization of the allicin compound and several other compounds, enhancing its antioxidant effects. The distinct garlic aroma is also neutralized during the process, making it preferable for those who would rather not radiate a constant aura of garlic throughout the day.

Aged Garlic Extract, or AGE for short, is a proprietary formulation of garlic that seeks to stabilize allicin and other compounds.
Aged Garlic Extract, or AGE for short, is a proprietary formulation of garlic that seeks to stabilize allicin and other compounds.


AGE has been featured extensively in academic studies, with many peer-reviewed analyses looking at aged garlic extract and the immune system and cardiovascular health.

When should I take garlic extract?

Short answer: Garlic extract supplements are best taken with any meal.

There is no particular time of day that seems to be best suited for taking garlic extract, however it is recommended to take it in combination with a meal, the reason being that the stomach's overall acidity is reduced while food is present, allowing the garlic extract to survive initial digestion and pass through the stomach into the intestine, which is where the absorption process takes place.

What else pairs well with garlic extract?

Short answer: While not found to provide additional benefits when taken at the exact same time, research has shown that garlic extract pairs well with B-complex, l-arginine, ubiquinol, vitamin B6, vitamin B9 and vitamin B12.

Also taken with ubiquinol, for cardiovascular health

One study tested a combination of aged garlic extract and CoQ10, known as ubiquinol in its refined form, to see if such a combination had favorable effect on atherosclerosis, a condition characterized by the narrowing and hardening of the arteries due to an accumulation of plaque in the artery walls.

After adjustment for age, gender, and other risk factors, it was found that the combined supplementation of aged garlic extract and CoQ10 was associated with a slower progression of atherosclerosis, as well as lower inflammatory markers associated with the condition.

Also taken with L-arginine and B-vitamins, for cardiovascular health

It has also been found that aged garlic extract, when combined with l-arginine and vitamins B6, B9 and B12, was likewise studied in relation to the progression of atherosclerosis and other cardiovascular risk factors.

Also taken with B-complex, for nutritional deficiencies and nervous system

People take garlic extract with B-complex for nutritional deficiencies, nervous system, heart health and cholesterol levels, and each one is worth having on its own as well as alongside the other.

What should I avoid taking garlic extract with?

Short answer: Avoid taking garlic extract supplements at the same time as bee propolis or alcohol.

Other blood-thinning supplements

Garlic extract has blood-thinning effects of its own, and so do vitamin E, bee propolis, fish oil and krill oil. All of them nudge clotting in the same direction, so the more of that list a routine carries, the further the combined effect goes.

Avoid taking garlic extract at the same time as alcohol

Alcohol and garlic both relax the stomach lining, so a garlic capsule taken on a heavy drinking evening is more likely to bring heartburn than either alone. Keep the capsule with a meal that doesn't carry alcohol, and leave a few hours between the two.

What are natural sources of garlic extract?

Short answer: Natural sources of garlic extract include garlic.

If you are interested in obtaining your daily garlic extract through your diet, you can often find it in:

You know it as a seasoning: crushed raw into dressings, sliced into warm oil at the start of a dish, roasted whole until soft and sweet, or dried and ground for the spice rack. Its sulfur compounds form only when the cells are broken by chopping, which is why a whole clove smells of so little and a freshly mashed one is so pungent.

Who should avoid taking garlic extract?

Short answer: Avoid taking garlic extract supplements if you have bleeding disorders or upcoming or recent surgery.

Before taking garlic extract supplements, check with your trusted healthcare professional if any of the following apply to you:

  • Bleeding disorders
  • Upcoming or recent surgery

Bleeding and surgery

Garlic extract thins the blood enough to matter before surgery and beside an anticoagulant, and the effect can persist for a week after the capsules stop, which is why it is important to stop taking it ahead of any planned operation.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional if you are suffering from any health conditions.

Possible side effects of garlic extract

Short answer: Side effects of garlic extract supplements can include breath, heartburn and bleeding tendency.

Possible side effects from taking garlic extract supplements may include (but are not limited to) the following:

  • Breath
  • Heartburn
  • Bleeding tendency

If you are experiencing negative side effects from taking garlic extract supplements, stop taking them immediately and reach out to your trusted healthcare professional.

Drug interactions with garlic extract

Short answer: Garlic extract supplements can interact with blood thinners and blood pressure medicines.

The medicines listed below are the ones most often named in interaction reports for garlic extract, but it is by no means a comprehensive list:

  • Blood thinners
  • Blood pressure medicines

Blood thinners

It is not recommended to take garlic extract together with any anticoagulant, or with blood-thinning medication, as garlic naturally already has a blood-thinning effect.

If you are taking any prescription drugs or medication, check with your trusted healthcare professional before taking garlic extract supplements.

Can I take garlic extract while pregnant or breastfeeding?

Short answer: Garlic extract supplements do not have sufficient safety data during pregnancy and breastfeeding.

Garlic as a food is ordinary during pregnancy, and the amount in a meal isn't the concern, but there are no human pregnancy trials of the extract. The concentrated extract is taken for blood pressure and cholesterol, and it thins the blood a little, which matters near delivery and beside a planned operation, so avoid taking it to be on the safe side.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional while pregnant or breastfeeding, or while attempting to conceive.

Where should I store garlic extract?

Short answer: You can store garlic extract supplements in the cupboard.

For optimal shelf life, it is recommended to keep garlic extract supplements stored in the cupboard. Always make sure the bottle or container is tightly closed, and kept away from sources of light, heat and humidity.

Garlic extract data sources & further reading

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    Garlic: Usefulness and Safety

    National Center for Complementary and Integrative HealthGovernment guidance

    https://www.nccih.nih.gov/health/garlicVisit https://www.nccih.nih.gov/health/garlic

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Last updated October 30th, 2026

Remember

A balanced diet and a healthy lifestyle always come first, and supplements are meant to be just that: supplementary. While every effort has been made to ensure that the data on this page is accurate, said accuracy can never be guaranteed. The information provided is not medical advice, it is not intended to cover all possible interactions or adverse effects, and neither is it a substitute for the expertise of professional healthcare practitioners. You are always encouraged to do your own research, and to consult with your trusted doctor or pharmacist before taking any supplements.

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