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When to take
Evening Primrose Oil

Evening primrose oil is a rich source of omega-6 and vitamin E, and has been used for centuries by Native Americans as a medicine.

What is evening primrose oil good for?

Short answer: Evening primrose oil is studied for skin health and the menstrual cycle.
The evening primrose plant, known scientifically as Oenothera biennis, is a flowering herb native to North America, and is named for its bright yellow flowers that bloom in the evening. Evening primrose oil is what is extracted from the seeds of the plant, and this oil has been used in traditional medicine for centuries by indigenous Native Americans.

The flower of the evening primrose plant is named for its ability to abruptly bloom in the early evening during the summer.
The flower of the evening primrose plant is named for its ability to abruptly bloom in the early evening during the summer.


Omega-6 content

The oil is thought to work mainly through its high content of linoleic acid and gamma-linoleic acid, which are omega-6 fatty acids, although it is also rich in other compounds, including vitamin E.

Areas of research

Despite its nutritional qualities, its long term safety profile, and its documented history in traditional use, research has not identified any clear benefits of evening primrose oil supplementation.

Despite this, there is a growing body of research into evening primrose oil and conditions such as dermatitis, arthritis, premenstrual syndrome, menopause symptoms and gastrointestinal upset, for example.

When should I take evening primrose oil?

Short answer: Evening primrose oil supplements are best taken with any meal, ideally with a meal that includes foods rich in dietary fat — meat, eggs, fatty fish, dairy, nuts, seeds, avocados, extra virgin olive oil, and similar.

Evening primrose oil can potentially cause side effects such as nausea or bloating when taken on an empty stomach. In addition to that, one of the main reasons why people take evening primrose oil is due to its omega-6 fatty acid content, and it is known that fatty acids are best absorbed when taken with a meal, especially one that contains healthy dietary fats.

There does not appear to be any conclusive time of day that is optimal for taking evening primrose oil, so you can fit it into your schedule with whichever meal is most suitable, at any time of day.

What else pairs well with evening primrose oil?

Short answer: While not found to provide additional benefits when taken at the exact same time, research has shown that evening primrose oil pairs well with fish oil, krill oil, omega-3 and vitex.

Also taken with omega-3

Being a source of omega-6 fatty acids, evening primrose oil is often taken in combination with omega-3 fatty acid supplements, such as fish oil or krill oil, in order to maintain a balanced ratio between omega-3s and omega-6s.

Also taken with vitex, for premenstrual syndrome and hormone balance

Vitex rounds out evening primrose oil by covering premenstrual syndrome, hormone balance and skin health, and the two make a natural combination for anyone already taking either.

What should I avoid taking evening primrose oil with?

Short answer: Avoid taking evening primrose oil supplements at the same time as omega-6 or pumpkin seed oil.

Avoid taking evening primrose oil at the same time as other omega-6 supplements

Its inherent omega-6 content also means that evening primrose oil should not be combined with additional omega-6 fatty acid supplementation, such as pumpkin seed oil for example, as excessive omega-6 intake, or rather an imbalance in the ratio between omega-3 and omega-6 fatty acids, can have negative health effects.

Avoid taking evening primrose oil at the same time as pumpkin seed oil

Pumpkin seed oil is another omega-6-rich oil, and taking it in the same sitting as evening primrose oil simply doubles the amount of omega-6 you take in.

What are natural sources of evening primrose oil?

The useful part of the plant are the seeds, and it is the oil that is pressed from the seeds that is the truly nutritious component. The gamma-linolenic acid contained in one softgel would mean eating a pile of seeds that nobody would manage, so there is no real substitute for the concentrated oil.

Who should avoid taking evening primrose oil?

Short answer: Avoid taking evening primrose oil supplements if you have epilepsy or seizure history or bleeding disorders.

Before taking evening primrose oil supplements, check with your trusted healthcare professional if any of the following apply to you:

  • Epilepsy or seizure history
  • Bleeding disorders

Epilepsy or seizure history

Case reports have linked evening primrose oil to seizure activity in people with a history of seizures or a seizure disorder.

Bleeding disorders

The oil also leans on the same clotting chemistry as other omega-6 fats, so if you suffer from a bleeding disorder or have surgery in the coming weeks, you should not take evening primrose oil.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional if you are suffering from any health conditions.

Possible side effects of evening primrose oil

Short answer: Side effects of evening primrose oil supplements can include nausea, headache and soft stools.

Possible side effects from taking evening primrose oil supplements may include (but are not limited to) the following:

  • Nausea
  • Headache
  • Soft stools

If you are experiencing negative side effects from taking evening primrose oil supplements, stop taking them immediately and reach out to your trusted healthcare professional.

Drug interactions with evening primrose oil

Short answer: Evening primrose oil supplements can interact with blood thinners.

The medicines listed below are the ones most often named in interaction reports for evening primrose oil, but it is by no means a comprehensive list:

  • Blood thinners

Blood thinners

Evening primrose oil carries a mild antiplatelet effect, which can add up with the anticoagulant effects of blood-thinning medications, so this combo is best avoided.

If you are taking any prescription drugs or medication, check with your trusted healthcare professional before taking evening primrose oil supplements.

Can I take evening primrose oil while pregnant or breastfeeding?

Short answer: Evening primrose oil supplements should be avoided during pregnancy and breastfeeding.

One important thing to note, you should not take evening primrose oil if you are pregnant, as doing so could endanger you, and potentially the baby.

Remember to always discuss any vitamins or supplements with your trusted healthcare professional while pregnant or breastfeeding, or while attempting to conceive.

Where should I store evening primrose oil?

Short answer: You can store evening primrose oil supplements in the fridge.

For optimal shelf life, it is recommended to keep evening primrose oil supplements stored in the fridge. Always make sure the bottle or container is tightly closed before putting it in the fridge.

Evening primrose oil data sources & further reading

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    Evening Primrose Oil: Usefulness and Safety

    National Center for Complementary and Integrative HealthGovernment guidance

    https://www.nccih.nih.gov/health/evening-primrose-oilVisit https://www.nccih.nih.gov/health/evening-primrose-oil

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Last updated October 3rd, 2026

Remember

A balanced diet and a healthy lifestyle always come first, and supplements are meant to be just that: supplementary. While every effort has been made to ensure that the data on this page is accurate, said accuracy can never be guaranteed. The information provided is not medical advice, it is not intended to cover all possible interactions or adverse effects, and neither is it a substitute for the expertise of professional healthcare practitioners. You are always encouraged to do your own research, and to consult with your trusted doctor or pharmacist before taking any supplements.

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